An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
ENTRAF ID | ENTRAF0001 |
Gene name | pyrR |
Uniprot ID | PYRR_BACSU |
Organism | Bacillus subtilis (strain 168) |
Aminoacid sequence | MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGIYLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVILVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSEKVMVQLDEVDQNDLVAIYENE |
FASTA file | Download |
Length | 181 |
Function Uniprot | Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. |
Role | Repressor |
Protein family | Pribosyltransferase |
Structure (PDB ID) | 1A3C |