An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
| ENTRAF ID | ENTRAF0001 |
| Gene name | pyrR |
| Uniprot ID | PYRR_BACSU |
| Organism | Bacillus subtilis (strain 168) |
| Aminoacid sequence | MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGIYLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVILVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSEKVMVQLDEVDQNDLVAIYENE |
| FASTA file | Download |
| Length | 181 |
| Function Uniprot | Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. |
| Role | Repressor |
| Protein family | Pribosyltransferase |
| Structure (PDB ID) | 1A3C |