An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
| ENTRAF ID | ENTRAF0002 |
| Gene name | sacY |
| Uniprot ID | SACY_BACSU |
| Organism | Bacillus subtilis (strain 168) |
| Aminoacid sequence | MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIEKTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSFAIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIHTARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAGESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQRSVAR |
| FASTA file | Download |
| Length | 280 |
| Function Uniprot | In the presence of sucrose, SacY is activated and prevents premature termination of transcription by binding to a RNA-antiterminator (RAT) sequence (partially overlapping with the terminator sequence) located upstream of the sacB gene. Formation of the SacY-RAT complex prevents alternative formation of the terminator, allowing transcription of the sacB gene. In the absence of sucrose, inhibition of SacY activity by SacX leads to termination of transcription. |
| Role | Activator |
| Protein family | BglG-like antiterminator proteins |
| Structure (PDB ID) | 1AUU |