ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0012
Gene name ethR
Uniprot ID ETHR_MYCTU
Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Aminoacid sequence MTTSAASQASLPRGRRTARPSGDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGENR
FASTA file Download
Length 216

Functional information

Function Uniprot Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).
Role Repressor
Protein family TetR/AcrR
Structure (PDB ID) 1T56

References

Pubmed ID 1 18985025
Pubmed ID 2 14651620
Pubmed ID 3 15722376
Pubmed ID 4 25581030
Pubmed ID 5 21818301

Experimental evidences

BPP, GEA, AS, CHS