An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
| ENTRAF ID | ENTRAF0020 |
| Gene name | spxA |
| Uniprot ID | SPX_BACSU |
| Organism | Bacillus subtilis (strain 168) |
| Aminoacid sequence | MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQVGYNEDEIRRFLPRKVRSFQLREAQRLAN |
| FASTA file | Download |
| Length | 131 |
| Function Uniprot | Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Negatively affects competence and sporulation. Its degradation by the MecA/ClpXP complex is needed for competence development. |
| Role | Repressor |
| Protein family | ArsC |
| Structure (PDB ID) | 1Z3E |