An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
ENTRAF ID | ENTRAF0038 |
Gene name | crp |
Uniprot ID | CRPL_MYCTU |
Organism | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Aminoacid sequence | MDEILARAGIFQGVEPSAIAALTKQLQPVDFPRGHTVFAEGEPGDRLYIIISGKVKIGRRAPDGRENLLTIMGPSDMFGELSIFDPGPRTSSATTITEVRAVSMDRDALRSWIADRPEISEQLLRVLARRLRRTNNNLADLIFTDVPGRVAKQLLQLAQRFGTQEGGALRVTHDLTQEEIAQLVGASRETVNKALADFAHRGWIRLEGKSVLISDSERLARRAR |
FASTA file | Download |
Length | 224 |
Function Uniprot | Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. The CRP regulon is predicted to contain about 115 genes. Some genes are activated by CRP (rpfA, whiB1) while others are repressed (fadD10). There are 2 CRP-binding sites in the promoter of whiB1, at low concentrations of CRP with or without cAMP transcription of whiB1 is enhanced via site CRP1, then repressed as site CRP2 is filled. |
Role | Activator; Repressor |
Protein family | Crp |
Structure (PDB ID) | 3D0S |
Pubmed ID 1 | 9634230 |
Pubmed ID 2 | 12218036 |
Pubmed ID 3 | 16946269 |
Pubmed ID 4 | 16267303 |
Pubmed ID 5 | 15882420 |
Pubmed ID 6 | 20028978 |
Pubmed ID 7 | 19193643 |
Pubmed ID 8 | 19740754 |
Pubmed ID 9 | 20338852 |
Pubmed ID 10 | 22074452 |
Pubmed ID 11 | 18985025 |
Pubmed ID 12 | 15882420 |
Pubmed ID 13 | 16267303 |
Pubmed ID 14 | 15722376 |
Pubmed ID 15 | 21199259 |
Pubmed ID 16 | 25581030 |
Pubmed ID 17 | 29165665 |
Pubmed ID 18 | 29670589 |
Pubmed ID 19 | 25940627 |
BPP, SM, AS, MIC, CHS |