An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
| ENTRAF ID | ENTRAF0125 |
| Gene name | Rv3488 |
| Uniprot ID | I6X7F9_MYCTU |
| Organism | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| Aminoacid sequence | MREFQRAAVRLHILHHAADNEVHGAWLTQELSRHGYRVSPGTLYPTLHRLEADGLLVSEQRVVDGRARRVYRATPAGRAALTEDRRALEELAREVLGGQSHTAGNGT |
| FASTA file | Download |
| Length | 107 |
| Function Uniprot | Transcription regulation and metal-detoxifying functions through which it may enhance intracellular survival of mycobacteria. Binds to its own promoter region and to the Rv1999c promoter region. It displays strong affinity for cadmium ions, but can also bind zinc, manganese and nickel. Expression increases the intracellular survival of recombinant M. smegmatis in murine macrophage cell line and increases its tolerance to cadmium ions. |
| Role | Unknown |
| Protein family | PadR |
| Structure (PDB ID) | 5ZHC |