ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0229
Gene name hrcA
Uniprot ID HRCA_MYCTU
Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Aminoacid sequence MGSADERRFEVLRAIVADFVATQEPIGSKSLVERHNLGVSSATVRNDMAVLEAEGYITQPHTSSGRVPTEKGYREFVDRLEDVKPLSSAERRAIQSFLESGVDLDDVLRRAVRLLAQLTRQVAVVQYPTLSTSTVRHLEVIALTPARLLMVVITDSGRVDQRIVELGDVIDDHQLAQLREILGQALEGKKLSAASVAVADLASQLGGAGGLGDAVGRAATVLLESLVEHTEERLLLGGTANLTRNAADFGGSLRSILEALEEQVVVLRLLAAQQEAGKVTVRIGHETASEQMVGTSMVSTAYGTAHTVYGGMGVVGPTRMDYPGTIASVAAVALYIGDVLGAR
FASTA file Download
Length 343

Functional information

Function Uniprot Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Role Repressor
Protein family HrcA
Structure (PDB ID) -

References

Pubmed ID 1 18985025
Pubmed ID 2 12368446
Pubmed ID 3 25581030
Pubmed ID 4 21818301

Experimental evidences

AS, MIC, CHS