ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0245
Gene name abrB
Uniprot ID ABRB_BACSU
Organism Bacillus subtilis (strain 168)
Aminoacid sequence MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEKIILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK
FASTA file Download
Length 96

Functional information

Function Uniprot Ambiactive repressor and activator of the transcription of genes expressed during the transition state between vegetative growth and the onset of stationary phase and sporulation. It controls the expression of genes spovG and tycA. AbrB binds to the tycA promoter region at two A- and T-rich sites, it may be the sole repressor of tycA transcription.
Role Activator; Repressor
Protein family MazE_antitoxin
Structure (PDB ID) 1YFB

References

Pubmed ID 1 3145384
Pubmed ID 2 2554317
Pubmed ID 3 7584024
Pubmed ID 4 9384377
Pubmed ID 5 2504584
Pubmed ID 6 1908787
Pubmed ID 7 15101989

Experimental evidences

BPP, BCE, SM