ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0293
Gene name cadC
Uniprot ID CADC_STAAU
Organism Staphylococcus aureus
Aminoacid sequence MKKKDTCEIFCYDEEKVNRIQGDLQTVDISGVSQILKAIADENRAKITYALCQDEELCVCDIANILGVTIANASHHLRTLYKQGVVNFRKEGKLALYSLGDEHIRQIMMIALAHKKEVKVNV
FASTA file Download
Length 122

Functional information

Function Uniprot Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Binds 2 metal ions per subunit. Metal binding to the N-terminal regulatory site causes the repressor to dissociate from the DNA.
Role Repressor
Protein family ArsR
Structure (PDB ID) 1U2W

References

Pubmed ID 1 2524829
Pubmed ID 2 1938959
Pubmed ID 3 7543476
Pubmed ID 4 11278706
Pubmed ID 5 12176999
Pubmed ID 6 11941514
Pubmed ID 7 15937183
Pubmed ID 8 19286656
Pubmed ID 9 16487591

Experimental evidences

BPP, SM