An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
| ENTRAF ID | ENTRAF0295 |
| Gene name | ccdA |
| Uniprot ID | CCDA_ECO57 |
| Organism | Escherichia coli O157:H7 |
| Aminoacid sequence | MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW |
| FASTA file | Download |
| Length | 72 |
| Function Uniprot | Antitoxin component of a toxin-antitoxin (TA) module which inhibits the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Binds to and blocks the activity of CcdB; will also remove bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdB (By similarity). |
| Role | Repressor |
| Protein family | CcdA |
| Structure (PDB ID) | 3TCJ |