ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0295
Gene name ccdA
Uniprot ID CCDA_ECO57
Organism Escherichia coli O157:H7
Aminoacid sequence MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW
FASTA file Download
Length 72

Functional information

Function Uniprot Antitoxin component of a toxin-antitoxin (TA) module which inhibits the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Binds to and blocks the activity of CcdB; will also remove bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdB (By similarity).
Role Repressor
Protein family CcdA
Structure (PDB ID) 3TCJ

References

Pubmed ID 1 9722640
Pubmed ID 2 9628576
Pubmed ID 3 9401024

Experimental evidences

PDB