An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
ENTRAF ID | ENTRAF0295 |
Gene name | ccdA |
Uniprot ID | CCDA_ECO57 |
Organism | Escherichia coli O157:H7 |
Aminoacid sequence | MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW |
FASTA file | Download |
Length | 72 |
Function Uniprot | Antitoxin component of a toxin-antitoxin (TA) module which inhibits the post-segregational killing (PSK) of plasmid-free cells, also referred to as a plasmid addiction system. Binds to and blocks the activity of CcdB; will also remove bound CcdB protein from the CcdB-GyrA complex by forming a CcdA-CcdB complex, a process termed rejuvenation. Functions as a transcriptional corepressor for the ccdAB operon, repression also requires CcdB (By similarity). |
Role | Repressor |
Protein family | CcdA |
Structure (PDB ID) | 3TCJ |