ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0298
Gene name ccpA
Uniprot ID CCPA_BACSU
Organism Bacillus subtilis (strain 168)
Aminoacid sequence MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIERLGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQNMEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAIDYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVAEGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFDNTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS
FASTA file Download
Length 334

Functional information

Function Uniprot Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. Interacts with either P-Ser-HPr or P-Ser-Crh, leading to the formation of a complex that binds to DNA at the catabolite-response elements (cre). Binding to DNA allows activation or repression of many different genes and operons.
Role Activator; Repressor
Protein family GalR/LacI
Structure (PDB ID) 1ZVV

References

Pubmed ID 1 1904524
Pubmed ID 2 9387221
Pubmed ID 3 9384377
Pubmed ID 4 7665492
Pubmed ID 5 10559165
Pubmed ID 6 11557150
Pubmed ID 7 16316990
Pubmed ID 8 16755587
Pubmed ID 9 21106498

Experimental evidences

BPP