ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0312
Gene name cmr
Uniprot ID CMR_MYCTU
Organism Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Aminoacid sequence MADRSVRPLRHLVHAVTGGQPPSEAQVRQAAWIARCVGRGGSAPLHRDDVSALAETLQVKEFAPGAVVFHADQTADGVWIVRHGLIELAVGSRRRRAVVNILHPGDVDGDIPLLLEMPMVYTGRALTQATCLFLDRQAFERLLATHPAIARRWLSSVAQRVSTAQIRLMGMLGRPLPAQVAQLLLDEAIDARIELAQRTLAAMLGAQRPSINKILKEFERDRLITVGYAVIEITDQHGLRARAQ
FASTA file Download
Length 244

Functional information

Function Uniprot Positively regulates the expression of at least groEL2. Cyclic AMP does not affect transcription in vitro. Metal-responsive transcriptional repressor for the cmt operon. Binding of cadmium or lead causes the repressor to dissociate from the DNA.
Role Activator
Protein family Crp
Structure (PDB ID) -

References

Pubmed ID 1 9634230
Pubmed ID 2 12218036
Pubmed ID 3 22464736
Pubmed ID 4 26358810
Pubmed ID 5 28482027
Pubmed ID 6 29165665

Experimental evidences

BPP