ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0314
Gene name codY
Uniprot ID CODY_BACSU
Organism Bacillus subtilis (strain 168)
Aminoacid sequence MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSRRGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVENRDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAEEIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIVNALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH
FASTA file Download
Length 259

Functional information

Function Uniprot DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase and sporulation. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.
Role Repressor
Protein family CodY
Structure (PDB ID) 2B0L

References

Pubmed ID 1 7783641
Pubmed ID 2 9384377
Pubmed ID 3 9298659
Pubmed ID 4 8830686
Pubmed ID 5 11331605
Pubmed ID 6 17218307

Experimental evidences

BPP