ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0331
Gene name cspD
Uniprot ID CSPD_ECOLI
Organism Escherichia coli (strain K12)
Aminoacid sequence MEKGTVKWFNNAKGFGFICPEGGGEDIFAHYSTIQMDGYRTLKAGQSVQFDVHQGPKGNHASVIVPVEVEAAVA
FASTA file Download
Length 74

Functional information

Function Uniprot Inhibits DNA replication at both initiation and elongation steps, most probably by binding to the opened, single-stranded regions at replication forks. Plays a regulatory role in chromosomal replication in nutrient-depleted cells.; Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR. Overproduction is toxic.
Role Repressor
Protein family CSD
Structure (PDB ID) -

References

Pubmed ID 1 2186030
Pubmed ID 2 8905232
Pubmed ID 3 9278503
Pubmed ID 4 16738553
Pubmed ID 5 9868784
Pubmed ID 6 1622933
Pubmed ID 7 11260474
Pubmed ID 8 19909729
Pubmed ID 9 20105222

Experimental evidences

BPP, BCE