ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0391
Gene name relE
Uniprot ID RELE_MYCTU
Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Aminoacid sequence MSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEIIHIARRSASYRMNPCRPR
FASTA file Download
Length 97

Functional information

Function Uniprot Toxic component of a toxin-antitoxin (TA) module. Has RNase activity (By similarity). Overexpression in M.tuberculosis or M.smegmatis inhibits colony formation in a bacteriostatic rather than bacteriocidal fashion. Its toxic effect is neutralized by coexpression with cognate antitoxin RelB (shown only for M.smegmatis).
Role Repressor
Protein family YoeB/Txe-like
Structure (PDB ID) -

References

Pubmed ID 1 19114484
Pubmed ID 2 9634230
Pubmed ID 3 15718296
Pubmed ID 4 19114484
Pubmed ID 5 20011113
Pubmed ID 6 20061486
Pubmed ID 7 20498855

Experimental evidences

GEA