ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0392
Gene name relF
Uniprot ID RELF_MYCTU
Organism Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Aminoacid sequence MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGEDEIRAEFGVPRRPH
FASTA file Download
Length 93

Functional information

Function Uniprot Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of toxin RelE2.; Induces its own promoter, in combination with RelG represses its own promoter. Has been seen to bind DNA in complex with toxin RelG but not alone.
Role Activator; Repressor
Protein family PhdYeFM_antitox
Structure (PDB ID) 3G5O

References

Pubmed ID 1 19114484
Pubmed ID 2 9634230
Pubmed ID 3 19114484
Pubmed ID 4 20011113
Pubmed ID 5 20498855

Experimental evidences

GEA