ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0409
Gene name rok
Uniprot ID ROK_BACSU
Organism Bacillus subtilis (strain 168)
Aminoacid sequence MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNGSPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDGTTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQSLIKMYPEVKKPYRGQYILEGEIESAESANE
FASTA file Download
Length 191

Functional information

Function Uniprot Repressor of comK, the master regulator of competence development. Overexpression seems to be lethal. Represses at least 20 genes that specify membrane-localized and secreted proteins, including some that encode products with antibiotic activity. Binds to many AT-rich sites in the chromosome, many of which are known or thought to derive from horizontal gene transfer; helps keep mobile element ICEBs1 quiescent in the genome. Binds to its own promoter and is thus probably autoregulatory.
Role Repressor
Protein family -
Structure (PDB ID) 5ZUX

References

Pubmed ID 1 9384377
Pubmed ID 2 15743949
Pubmed ID 3 11849533
Pubmed ID 4 21085634

Experimental evidences

GEA