ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0416
Gene name saeR
Uniprot ID SAER_STAA8
Organism Staphylococcus aureus (strain NCTC 8325)
Aminoacid sequence MTHLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGYDIVKEMKRQKLDIPFIYLTAKTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMKKYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFELLWYLASRENEVISKSELLEKVWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR
FASTA file Download
Length 228

Functional information

Function Uniprot Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs near the promoter sequences of target genes. SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (Hla, Hlb), Coa, DNase, Spa and cell wall-associated proteins (Emp, Eap, FnbA). Acts probably downstream of the Agr system in the regulatory cascade of virulence factors.
Role Activator
Protein family Trans_reg_C
Structure (PDB ID) 4QWQ

References

Pubmed ID 1 14523104
Pubmed ID 2 14563862
Pubmed ID 3 7922890
Pubmed ID 4 8742355
Pubmed ID 5 9211714
Pubmed ID 6 10436918
Pubmed ID 7 11442841
Pubmed ID 8 12732971
Pubmed ID 9 14523104
Pubmed ID 10 15576798
Pubmed ID 11 15941988
Pubmed ID 12 17041853

Experimental evidences

PDB