ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0418
Gene name saeR
Uniprot ID SAER_STAAE
Organism Staphylococcus aureus (strain Newman)
Aminoacid sequence MTHLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGYDIVKEMKRQKLDIPFIYLTAKTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMKKYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFELLWYLASRENEVISKSELLEKVWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR
FASTA file Download
Length 228

Functional information

Function Uniprot Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs near the promoter sequences of target genes. SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (hla, Hlb, HlgC), Coa, DNase, Spa and cell wall-associated proteins (Emp, Eap, FnbA, FnbB, Efb). Represses the expression of type 5 capsular polysaccharide (cap operon). Also modulates the expression of several other genes.
Role Activator; Repressor
Protein family Trans_reg_C
Structure (PDB ID) -

References

Pubmed ID 1 18955469
Pubmed ID 2 10436918
Pubmed ID 3 14563862
Pubmed ID 4 17951380
Pubmed ID 5 7922890
Pubmed ID 6 9211714
Pubmed ID 7 11442841
Pubmed ID 8 15908369
Pubmed ID 9 15941988
Pubmed ID 10 16734776
Pubmed ID 11 16861653
Pubmed ID 12 17079681

Experimental evidences

GEA