An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
| ENTRAF ID | ENTRAF0427 |
| Gene name | sarA |
| Uniprot ID | SARA_STAAW |
| Organism | Staphylococcus aureus (strain MW2) |
| Aminoacid sequence | MAITKINDCFELLSMVTYADKLKSLIKKEFSISFEEFAVLTYISENKEKEYYLKDIINHLNYKQPQVVKAVKILSQEDYFDKKRNEHDERTVLILVNAQQRKKIESLLSRVNKRITEANNEIEL |
| FASTA file | Download |
| Length | 124 |
| Function Uniprot | Global regulator with both positive and negative effects that controls the expression of several virulence factors and the biofilm formation process in a cell density-dependent manner (By similarity). Required for transcription of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus. Negatively regulates the expression of spa (protein A) and aur (metalloprotease aureolysin). |
| Role | Activator; Repressor |
| Protein family | MarR |
| Structure (PDB ID) | 2FNP |