ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0432
Gene name sarS
Uniprot ID SARS_STAA8
Organism Staphylococcus aureus (strain NCTC 8325)
Aminoacid sequence MKYNNHDKIRDFIIIEAYMFRFKKKVKPEVDMTIKEFILLTYLFHQQENTLPFKKIVSDLCYKQSDLVQHIKVLVKHSYISKVRSKIDERNTYISISEEQREKIAERVTLFDQIIKQFNLADQSESQMIPKDSKEFLNLMMYTMYFKNIIKKHLTLSFVEFTILAIITSQNKNIVLLKDLIETIHHKYPQTVRALNNLKKQGYLIKERSTEDERKILIHMDDAQQDHAEQLLAQVNQLLADKDHLHLVFE
FASTA file Download
Length 250

Functional information

Function Uniprot Transcriptional regulator that controls expression of some virulence factors in a cell density-dependent manner. Acts as an activator of the gene encoding protein A (spa). Negatively regulates the expression of alpha-hemolysin (hla).
Role Activator; Repressor
Protein family MarR
Structure (PDB ID) 1P4X

References

Pubmed ID 1 10931334
Pubmed ID 2 11254606
Pubmed ID 3 12933857
Pubmed ID 4 12511508
Pubmed ID 5 15126456
Pubmed ID 6 15175287
Pubmed ID 7 15731040
Pubmed ID 8 16128400
Pubmed ID 9 12837797

Experimental evidences

BPP