An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
| ENTRAF ID | ENTRAF0435 |
| Gene name | sarT |
| Uniprot ID | SART_STAA8 |
| Organism | Staphylococcus aureus (strain NCTC 8325) |
| Aminoacid sequence | MNDLKSKSNIKLMKRVLTTYELRKYLKKYFCLTLDNYLVLAYLDVFKNDEGKYFMRDIISYIGIDQSRIVKSVKDLSKKGYLNKCRDPHDSRNVIIVVSVKQHNYIKNLLSEININET |
| FASTA file | Download |
| Length | 118 |
| Function Uniprot | Transcriptional regulator acting as an intermediary between major regulators sarA and agr and virulence genes. Represses alpha-hemolysin (hla) gene expression. Down-regulates agr RNAIII expression by repressing sarU, a positive activator of agr expression. Up-regulates sarS, which induces the expression of the cell wall-associated protein A (spa). |
| Role | Activator; Repressor |
| Protein family | HTH_27 |
| Structure (PDB ID) | - |