An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
ENTRAF ID | ENTRAF0466 |
Gene name | alpA |
Uniprot ID | ALPA_ECOLI |
Organism | Escherichia coli (strain K12) |
Aminoacid sequence | MNNRSAVRILRLPAVIQKTGMARATIYDWLNPKSPRYDATFPKKRMLGVKSVGWIEAEIDEWLSQRCKLI |
FASTA file | Download |
Length | 70 |
Function Uniprot | Positive regulator of the expression of the slpA gene. When overexpressed, leads to suppression of the capsule overproduction and UV sensitivity phenotypes of cells mutant for the Lon ATP-dependent protease. Part of the cryptic P4-like prophage CP4-57. Overexpression of AlpA leads to excision of the CP4-57 prophage by IntA. This inactivates ssrA (the gene upstream of the prophage) that encodes tmRNA which is required to rescue stalled ribosomes in a process known as trans-translation. |
Role | Activator |
Protein family | Phage_AlpA |
Structure (PDB ID) | - |