ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0487
Gene name cra
Uniprot ID CRA_ECOLI
Organism Escherichia coli (strain K12)
Aminoacid sequence MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIANYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDAIIVSTSLPPEHPFYQRWANDPFPIVALDRALDREHFTSVVGADQDDAEMLAEELRKFPAETVLYLGALPELSVSFLREQGFRTAWKDDPREVHFLYANSYEREAAAQLFEKWLETHPMPQALFTTSFALLQGVMDVTLRRDGKLPSDLAIATFGDNELLDFLQCPVLAVAQRHRDVAERVLEIVLASLDEPRKPKPGLTRIKRNLYRRGVLSRS
FASTA file Download
Length 334

Functional information

Function Uniprot Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. Activates transcription of genes encoding biosynthetic and oxidative enzymes (involved in Krebs cycle, glyoxylate shunt and gluconeogenesis, such as ppsA and fbp). Represses genes involved in sugar catabolism, such as fruB, pfkA, pykF and adhE. Binds asymmetrically to the two half-sites of its operator.
Role Activator; Repressor
Protein family GalR/LacI
Structure (PDB ID) 1UXC

References

Pubmed ID 1 2198273
Pubmed ID 2 1851954
Pubmed ID 3 1630901
Pubmed ID 4 9278503
Pubmed ID 5 16738553
Pubmed ID 6 8230205
Pubmed ID 7 8195118
Pubmed ID 8 8577250
Pubmed ID 9 8550429
Pubmed ID 10 8858581
Pubmed ID 11 9084760
Pubmed ID 12 8655535
Pubmed ID 13 9371462
Pubmed ID 14 16115199
Pubmed ID 15 9237914

Experimental evidences

BPP, SM, GEA