An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
ENTRAF ID | ENTRAF0487 |
Gene name | cra |
Uniprot ID | CRA_ECOLI |
Organism | Escherichia coli (strain K12) |
Aminoacid sequence | MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGRTRSIGLVIPDLENTSYTRIANYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDAIIVSTSLPPEHPFYQRWANDPFPIVALDRALDREHFTSVVGADQDDAEMLAEELRKFPAETVLYLGALPELSVSFLREQGFRTAWKDDPREVHFLYANSYEREAAAQLFEKWLETHPMPQALFTTSFALLQGVMDVTLRRDGKLPSDLAIATFGDNELLDFLQCPVLAVAQRHRDVAERVLEIVLASLDEPRKPKPGLTRIKRNLYRRGVLSRS |
FASTA file | Download |
Length | 334 |
Function Uniprot | Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. Activates transcription of genes encoding biosynthetic and oxidative enzymes (involved in Krebs cycle, glyoxylate shunt and gluconeogenesis, such as ppsA and fbp). Represses genes involved in sugar catabolism, such as fruB, pfkA, pykF and adhE. Binds asymmetrically to the two half-sites of its operator. |
Role | Activator; Repressor |
Protein family | GalR/LacI |
Structure (PDB ID) | 1UXC |
Pubmed ID 1 | 2198273 |
Pubmed ID 2 | 1851954 |
Pubmed ID 3 | 1630901 |
Pubmed ID 4 | 9278503 |
Pubmed ID 5 | 16738553 |
Pubmed ID 6 | 8230205 |
Pubmed ID 7 | 8195118 |
Pubmed ID 8 | 8577250 |
Pubmed ID 9 | 8550429 |
Pubmed ID 10 | 8858581 |
Pubmed ID 11 | 9084760 |
Pubmed ID 12 | 8655535 |
Pubmed ID 13 | 9371462 |
Pubmed ID 14 | 16115199 |
Pubmed ID 15 | 9237914 |
BPP, SM, GEA |