ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0490
Gene name csgD
Uniprot ID CSGD_ECOLI
Organism Escherichia coli (strain K12)
Aminoacid sequence MFNEVHSIHGHTLLLITKSSLQATALLQHLKQSLAITGKLHNIQRSLDDISSGSIILLDMMEADKKLIHYWQDTLSRKNNNIKILLLNTPEDYPYRDIENWPHINGVFYSMEDQERVVNGLQGVLRGECYFTQKLASYLITHSGNYRYNSTESALLTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWANDNLRR
FASTA file Download
Length 216

Functional information

Function Uniprot The master regulator for adhesive curli fimbriae expression; necessary for transcription of the csgBAC/ymdA operon. Plays a positive role in biofilm formation. May have the capability to respond to starvation and/or high cell density by activating csgBA transcription. Low-level constitutive expression confers an adherent curli fimbriae-expressing phenotype, up-regulates 10 genes and down-regulates 14 others.
Role Activator; Repressor
Protein family GerE
Structure (PDB ID) -

References

Pubmed ID 1 8817489
Pubmed ID 2 8905232
Pubmed ID 3 9278503
Pubmed ID 4 16738553
Pubmed ID 5 16513732
Pubmed ID 6 17010156

Experimental evidences

BPP, SM, GEA