ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0494
Gene name cusR
Uniprot ID CUSR_ECOLI
Organism Escherichia coli (strain K12)
Aminoacid sequence MKLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIIESQFQVADLMVDLVSRKVTRSGTRITLTSKEFTLLEFFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRGKIDNDFEPKLIQTVRGVGYMLEVPDGQ
FASTA file Download
Length 227

Functional information

Function Uniprot Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA and plasmid pRJ1004 gene pcoE in response to increasing levels of copper ions, and probably silver ions. Can also increase the basal-level expression of copper resistance gene operon pcoABCD.
Role Activator
Protein family Trans_reg_C
Structure (PDB ID) -

References

Pubmed ID 1 11004187
Pubmed ID 2 8905232
Pubmed ID 3 9278503
Pubmed ID 4 16738553
Pubmed ID 5 11399769
Pubmed ID 6 11283292
Pubmed ID 7 15522865

Experimental evidences

BPP, SM, GEA