ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0497
Gene name cytR
Uniprot ID CYTR_ECOLI
Organism Escherichia coli (strain K12)
Aminoacid sequence MKAKKQETAATMKDVALKAKVSTATVSRALMNPDKVSQATRNRVEKAAREVGYLPQPMGRNVKRNESRTILVIVPDICDPFFSEIIRGIEVTAANHGYLVLIGDCAHQNQQEKTFIDLIITKQIDGMLLLGSRLPFDASIEEQRNLPPMVMANEFAPELELPTVHIDNLTAAFDAVNYLYEQGHKRIGCIAGPEEMPLCHYRLQGYVQALRRCGIMVDPQYIARGDFTFEAGSKAMQQLLDLPQPPTAVFCHSDVMALGALSQAKRQGLKVPEDLSIIGFDNIDLTQFCDPPLTTIAQPRYEIGREAMLLLLDQMQGQHVGSGSRLMDCELIIRGSTRALP
FASTA file Download
Length 341

Functional information

Function Uniprot This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors.
Role Repressor
Protein family GalR/LacI
Structure (PDB ID) 2LCV

References

Pubmed ID 1 3515317
Pubmed ID 2 8346018
Pubmed ID 3 9278503
Pubmed ID 4 16738553
Pubmed ID 5 2162050
Pubmed ID 6 1649947
Pubmed ID 7 1327747

Experimental evidences

BPP, SM, GEA