An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
| ENTRAF ID | ENTRAF0515 |
| Gene name | fis |
| Uniprot ID | FIS_ECOLI |
| Organism | Escherichia coli (strain K12) |
| Aminoacid sequence | MFEQRVNSDVLTVSTVNSQDQVTQKPLRDSVKQALKNYFAQLNGQDVNDLYELVLAEVEQPLLDMVMQYTRGNQTRAALMMGINRGTLRKKLKKYGMN |
| FASTA file | Download |
| Length | 98 |
| Function Uniprot | Activates ribosomal RNA transcription, as well other genes. Plays a direct role in upstream activation of rRNA promoters. Binds to a recombinational enhancer sequence that is required to stimulate hin-mediated DNA inversion. Prevents initiation of DNA replication from oriC. Binds to hundreds of transcriptionally active and inactive AT-rich sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome. |
| Role | Activator; Repressor |
| Protein family | Fis |
| Structure (PDB ID) | 1ETK |