An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
| ENTRAF ID | ENTRAF0534 |
| Gene name | hipB |
| Uniprot ID | HIPB_ECOLI |
| Organism | Escherichia coli (strain K12) |
| Aminoacid sequence | MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPESTEQQNLEW |
| FASTA file | Download |
| Length | 88 |
| Function Uniprot | Antitoxin component of a type II toxin-antitoxin (TA) module. Neutralizes the toxic effect of cognate toxin HipA. Also neutralizes the toxic effect of non-cognate toxin YjjJ. Binds to operator sites with the consensus sequence 5-'TATCCN(8)GGATA-3' to repress the hipBA operon promoter; binding of HipB(2) to DNA induces a 70 degree bend. This forces HipA dimerization, which blocks HipA's active site and thus its toxic action. May play a role in biofilm formation. |
| Role | Repressor |
| Protein family | SinR |
| Structure (PDB ID) | 2WIU |