ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0540
Gene name ihfA
Uniprot ID IHFA_ECOLI
Organism Escherichia coli (strain K12)
Aminoacid sequence MALTKAEMSEYLFDKLGLSKRDAKELVELFFEEIRRALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVENASPKDE
FASTA file Download
Length 99

Functional information

Function Uniprot One of the 2 subunits of integration host factor (IHF), a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Binds to hundreds of transcriptionally inactive, AT-rich DNA sites, approximately half its binding sites are in non-coding DNA, which only accounts for about 10% of the genome.
Role Activator; Repressor
Protein family Bac_DNA_binding
Structure (PDB ID) 1IHF

References

Pubmed ID 1 26527724
Pubmed ID 2 16963779

Experimental evidences

BPP, SM, GEA