ENTRAF

An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.

Transcription factor information

General information

ENTRAF ID ENTRAF0601
Gene name b2217
Uniprot ID RCSB_ECOLI
Organism Escherichia coli (strain K12)
Aminoacid sequence MNNMNVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPGDKYGDGITLIKYIKRHFPSLSIIVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKFTPESVSRLLEKISAGGYGDKRLSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALLNYLSSVTLSPADKD
FASTA file Download
Length 216

Functional information

Function Uniprot Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. Can function both in an RcsA-dependent or RcsA-independent manner. The system regulates expression of numerous genes, including genes involved in colanic acid capsule synthesis, biofilm formation, cell division and outer membrane proteins synthesis. Also involved, with GadE, in control of glutamate-dependent acid resistance, and, with BglJ, in derepression of the cryptic bgl operon. The RcsB-BglJ activity is probably independent of RcsB phosphorylation.
Role Activator; Repressor
Protein family GerE
Structure (PDB ID) 5I4C

References

Pubmed ID 1 1597415
Pubmed ID 2 2404948
Pubmed ID 3 8366025
Pubmed ID 4 9097040
Pubmed ID 5 9278503
Pubmed ID 6 16738553
Pubmed ID 7 1597415
Pubmed ID 8 11309126
Pubmed ID 9 13129944
Pubmed ID 10 19240136
Pubmed ID 11 20952573

Experimental evidences

BPP, SM, GEA