An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
| ENTRAF ID | ENTRAF0623 |
| Gene name | trpR |
| Uniprot ID | TRPR_ECOLI |
| Organism | Escherichia coli (strain K12) |
| Aminoacid sequence | MAQQSPYSAAMAEQRHQEWLRFVDLLKNAYQNDLHLPLLNLMLTPDEREALGTRVRIVEELLRGEMSQRELKNELGAGIATITRGSNSLKAAPVELRQWLEEVLLKSD |
| FASTA file | Download |
| Length | 108 |
| Function Uniprot | This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. |
| Role | Repressor |
| Protein family | TrpR |
| Structure (PDB ID) | 1CO0 |