An Encyclopedia of well-annotated DNA-binding TRanscription factors in Bacteria and Archaea.
| ENTRAF ID | ENTRAF0660 |
| Gene name | higB |
| Uniprot ID | HIGB_ECOLI |
| Organism | Escherichia coli (strain K12) |
| Aminoacid sequence | MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKCYIREVMTHKEYDFFTAVHRTKGKK |
| FASTA file | Download |
| Length | 104 |
| Function Uniprot | Toxic component of a type II toxin-antitoxin (TA) module. A probable translation-dependent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase. mRNA interferases play a role in bacterial persistence to antibiotics; overexpression of this protein induces persisters resistant to ciprofloxacin and ampicillin. |
| Role | Repressor |
| Protein family | HigB_toxin |
| Structure (PDB ID) | 5IFG |